Cormorant Pharmaceuticals’ business model is based on the principle of combining new research findings with existing drug substances in order to bring innovation faster to the patient.

Learn more


Test tubes

Our Product

Our first product in development is HuMax-IL8,  a medicine that inhibits the effects of interleukin 8 (IL-8), a chemokine that was recently shown to be an important target for cancer stem cells in several cancers, including breast, colorectal and liver cancer. We have a partnership with Genmab for HuMax-IL8 and we anticipate this will be our first product in the clinic.

Read more about cancer stem cells and IL-8 and HuMax-IL8.


Interleukin-8 is a factor that has been shown to be involved in the progression of many cancer forms by stimulating cancer growth, angiogensis and metastais. Recent research has also shown that IL-8 plays an important role in metastasis and epithelial mesenchymal transition (EMT) as well as cancer stem cell renewal. Moreover, IL-8 is involved in tumor immunosuppression and pre-clinical data showed that inhibition of IL-8 signaling acts synergistically with PD-1 inhibition.

Read more

Present day

Cancer treatment outcomes have improved substantially over the last decades, but many forms of cancer are still incurable if detected too late. There is a large medical need for improved therapies for those patients. Targeting cancer stem cells holds up the potential to improve on current treatment outcomes by reducing the risk of treatment failure and recurrence of the disease.

Read more

Our solution

With our first Product in development, HuMax-IL8, we are targeting cancer spread and cancer stem cells. HuMax-IL8 is a fully human antibody targeting interleukin-8. The antibody binds IL-8 with high affinity and specificity and has been through pre-clinical dvelopment as well as a phase I/II trial in patients.

Read more

Our vision

Our vision for HuMax-IL8 is that the inhibition of IL-8 will target the aggressive behaviour of cancer cells and cancer stem cells in several cancer forms. This will then increase the efficacy of existing cancer therapies as well as reduce the resistance to them. This will in turn lead to better disease control and fewer recurrencies.

Read more

Recent stories


Leukemia stem cells might be targeted by IL-8 inhibition

A new paper in the journal Blood indicates that lekemia stem cells in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) could be targeted by IL8-CXCR2 inhibition. Despite use of different chemtherapeutic agents and newer targeted agents, outcomes for patients remain poor. The disease course often leads to relapse or failure to achieve durable remission, […]

Read more

IL-8 signaling involved in tumor immunosuppression – new study shows

  A paper published recently in Science Translational Medicine has elegantly shown that upregulated IL-8 signaling is involved in protecting tumors from the immune system. The tumors seem to be able to produce IL-8 in large quantities in pediatric patients with sarcoma. Immune suppression is achieved by the tumors in different ways, but the mechanism mediated […]

Read more